Practices This retrospective study included 225 clients managed from COVID-19 into the duration from 1 to 30 September 2021 at the Clinic for Infectious Diseases, University Clinical Centre Tuzla (UCC Tuzla). For the diagnosis confirmation of Covid-19, RTPCR was utilized. Patients were split in 2 teams fully vaccinated with two doses of vaccine, and non-vaccinated or partly vaccinated. Results Of 225 customers, 120 (53.3%) had been females, and 105 (46.7%) males. Mean age had been 65.6 years. There have been 26 (11.6%) fully vaccinated patients. Most typical symptoms in unvaccinated patients were fatigue (70.9%), cough (70.4%) and temperature (69.8%), plus in vaccinated fever (76.9%), fatigue (69.2%) and coughing (46.2%). Cough was more widespread in unvaccinated patients (p=0.013). Fatal outcome took place in 84 (37.3%) clients. Transfer to the Intensive Care Unit (ICU) and older age had an increased chance of demise (p less then 0.001). Older age clients were more likely to have comorbidities like atrial fibrillation (p=0.017), high blood pressure (p less then 001) and diabetes mellitus (p=0.002). Atrial fibrillation (p less then 0.001), high blood pressure (p less then 0.001), diabetes mellitus (p=0.009) and reputation for stroke (p=0.026), were associated with deadly outcome in unvaccinated clients, additionally did a shorter duration of illness ahead of hospitalization (p less then 0.001) and faster duration of hospitalization (p=0.002). Conclusion elder patients with comorbidities, along with those who are not vaccinated against COVID-19, were at greater risk for severe form of the disease and bad outcome.Aim To determine risk facets in charge of establishing postoperative complications following the thoracic aorta reconstructive surgery. Methods Medical files of 100 clients, that has undergone elective or emergency thoracic aorta reconstructive surgery at the Clinic for Cardiovascular Surgical treatment, University Clinical Center Tuzla, had been analysed. Intraoperative information as cross-clamp time (CCT), duration of cardiopulmonary bypass (CPBT) and hypothermic circulatory arrest time (HCAT) had been examined. Univariate analysis had been utilized to show risk aspects for developing postoperative cardiac, breathing, surgical and renal complications. Results Between May 2019 and April 2021, 48 Bentall processes (BP), 23 ascending aortic replacements (AAR), 20 BP and coronary artery bypass grafting (CABG) and 9 aortic valve replacements (AVR) with AAR had been performed. Incidence of postoperative complications when you look at the optional and crisis groups was the following respiratory 20% vs 38% (p=0.049), cardiac 18% vs 70% (p=0.015), renal 16% vs 48% (p=0.027) and medical 4% vs 6% (p>0.05). Intrahospital thirty day period morbidity was 44% with death price of 13%. The outcomes indicated that CPBT>180 minutes ended up being biogenic amine a risk factor for respiratory (p=0.034), cardiac (p=0.020) and renal (p=0.027) postoperative problems after severe type A aortic dissection surgery. Conclusion CPBT > 180 min is a risk factor for postoperative improvement respiratory, cardiac and renal complications. Postoperative cardiac and renal problems were connected with longer HCAT.Aim To research analgesic and side effects of different doses of fentanyl in combination with propofol for colonoscopy. Techniques This prospective randomized double-blind study conducted between 2019 and 2020 included 64 clients. Clients were randomized Group 1 (fentanyl 0.5 μg/kg) and Group 2 (fentanyl 1.0 μg/kg) in both combination with propofol. Ramsay sedation rating (RSS) ended up being gotten at 5 with an additional dose of propofol. The primary result had been the in-patient’s postprocedural pain and bad activities during and after the procedure. Results The RSS means were statistically reduced for Group 2 in the beginning and each five full minutes of the procedure. Mean arterial pressure (MAP) for Group 2 (initially, 5, 25 and 30 min) ended up being dramatically lower (p=0.000, and heart rate (hour) ended up being significantly higher for Group 1 (throughout the entire treatment) (p=0.000) than in another group; peripheral oxygen saturation (SpO2 ) ended up being somewhat reduced for dimensions within both groups (Group 1, 5, 10, 15 min; Group 2, 5, 10,15 min) (p=0.000 and p=0.000, respectively). Anxiousness (p=0.010), weakness (p=0.000) and confusion (p=0.023) proved to be substantially greater for Group 1, and hypotension (p=0.001) for Group 2 compared to another group. No statistical significance of Visual Analogue Pain Scale (VAS) (p=0.501) and Aldrete recovery score (ARS) (p=0.845) ended up being found. Conclusion There was no significance in postprocedural abdominal discomfort amongst the selection of patients administered fentanyl at a dose of 0.5 μg/kg and the selection of customers administered fentanyl at a dose of 1.0 μg/kg; however, prevalence of problems ended up being more Phycocyanobilin concentration significant into the group with a fentanyl at a dose of 0.5 μg/kg.Aim To figure out a prognostic value of cerebral blood flow parameters when it comes to development of neurological sequelae in term neonates with hypoxic ischaemic encephalopathy (HIE). Techniques We evaluated health records of 47 term neonates with HIE whom survived until the chronilogical age of 12 months of life. In line with the Sarnat and Sarnat clinical score, neonates had been divided in to 3 groups mild HIE, reasonable HIE and serious HIE. All included neonates had the color Doppler brain sonography carried out in the 1st a day of life. The neurologic assessment was done in the age 12 months of life utilizing the cell-free synthetic biology Denver Developmental Screening Test (DDST). Reasoning regression evaluation was done making use of the color doppler brain sonography parameters with the development of neurologic impairment while the main outcome. Outcomes Out of 47 neonates, 19 (40.4%) had been with moderate, 17 (36.2%) with reasonable and 11 (23.4%) with extreme HIE. The values of cerebral circulation parameters and weight list (RI) dramatically correlated using the neurologic impairment in the age 12 months of life (p less then 0.001). The limit worth of RI showing poor people neurodevelopmental result was 0.81, sensitiveness 80%, specificity 85.3%, positive predictive worth 52.2% and negative predictive price 95.2percent.